Characterization of vascular neuropeptide Y receptors
نویسندگان
چکیده
منابع مشابه
New Antagonist Agents of Neuropeptide Y Receptors
The Neuropeptide Y (NPY) is a peptide of 36 amino acids, similar to the peptide YY (PYY) and to the pancreatic polypeptides (PP). At first, separated from the pig brain, the NPY is well-distributed in the mammals at the level of the central and peripheric nervous system. This neurotransmitter is present in strong concentrations in the nervous fiber of the brain, but equally as strong in the hea...
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Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy. The success encountered with radiolabeled somatostatin analogs is probably the first of a long list, a...
متن کاملPharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y/Peptide YY receptors.
1229U91 (GW1229 or GR231118) [lle,Glu,Pro,Dpr,Tyr, Arg,Leu,Arg, Tyr-NH(2))2 cyclic (2,4'),(2'4)-diamide] has been reported by several research groups to be a potent antagonist at the Y1 neuropeptide Y (NPY) receptor subtype. However, 1229U91 also displaces (125)I-peptide YY (PYY) with high affinity from the Y4 subtype. Previously, we reported that 1229U91 had full agonist properties for the Y4 ...
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BACKGROUND Female Aedes aegypti mosquitoes are the principal vector for dengue fever, causing 50-100 million infections per year, transmitted between human and mosquito by blood feeding. Ae. aegypti host-seeking behavior is known to be inhibited for three days following a blood meal by a hemolymph-borne humoral factor. Head Peptide-I is a candidate peptide mediating this suppression, but the me...
متن کاملPharmacological Characterization of I-1229U91 Binding to Y1 and Y4 Neuropeptide Y/Peptide YY Receptors
1229U91 (GW1229 or GR231118) [lle,Glu,Pro,Dpr,Tyr, Arg,Leu,Arg,Tyr-NH2)2 cyclic (2,49),(294)-diamide] has been reported by several research groups to be a potent antagonist at the Y1 neuropeptide Y (NPY) receptor subtype. However, 1229U91 also displaces I-peptide YY (PYY) with high affinity from the Y4 subtype. Previously, we reported that 1229U91 had full agonist properties for the Y4 receptor...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1992
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1992.tb14208.x